We recommend future studies be conducted in people with impaired glucose tolerance (following criteria defined by the American Diabetes Association) using daily doses of chromium picolinate providing ≥200–1,000 µg of elemental chromium for at least 90 days. For these reasons, we believe study subjects in the active group may have been administered daily doses of 50 µg elemental chromium, twice daily. It was also interesting to note that although the serum chromium levels significantly rose in the active group, the serum chromium levels were not significantly higher in the active group than in the placebo group after 3 months of supplementation (active group 5.2 ± 8.9 nmol/l, placebo group 4.4 ± 4.0 nmol/l). The study was conducted in Australia, and the 50-µg elemental chromium dose is also the maximum daily dose allowed by the Australian Therapeutic Goods Administration (3). A daily dose of 200–1,000 µg of elemental chromium, as chromium picolinate, is the efficacious dosage range used in previous studies.īullivants Natural Health Products, the supplier of the study products used by the authors, stated that 400 µg of the chromium picolinate product they produce yields 50 µg of elemental chromium. An elemental chromium dose of 100 µg a day is half of the suggested minimum amount (200 µg) of elemental chromium previously shown to exhibit efficacy in glucose and lipid metabolism (2). However, chromium picolinate administered at 800 µg per day yields a daily dose of 100 µg per day of elemental chromium (i.e., chromium picolinate contains 12.4% elemental chromium). The authors stated that the chromium picolinate "dose (at 800 µg/day) was at the higher end of the ranges used in previous studies" (1). The lack of effect described by the authors may be explained by the apparent low dose of elemental chromium used in the study. " The results are in conflict with other clinical studies that showed chromium picolinate can enhance or normalize impaired glucose metabolism, as described in a recent review (2). In this study, the authors stated that they "found no beneficial effect of chromium supplementation in the treatment of people with IGT. (1) with great interest and feel that it warrants comment. We read the recent article by Gunton et al. Technical Services & Scientific Affairs Department, Nutrition 21, Inc., Purchase, New YorkĪddress correspondence to Vijaya Juturu, PhD, Nutrition 21, Inc., 4 Manhattanville Rd., Purchase, NY 10577. James Komorowski, MS and Vijaya Juturu, PHD
When to take chromium picolinate trial#
Click to expand.Letters: Comments and ResponsesĬhromium Supplementation Does Not Improve Glucose Tolerance, Insulin Sensitivity, or Lipid Profile: A Randomized, Placebo-Controlled, Double-Blind Trial of Supplementation in Subjects With Impaired Glucose Tolerance
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